CORA
Cork Open Research Archive (CORA) is UCC’s Open Access institutional repository which enables UCC researchers to make their research outputs freely available and accessible.
UCC Research Communities
Recent Submissions
A review of DFOS sensors installation methods for curved surfaces in tunnels
(CRC Press / Balkema, 2024-08-26) Zhang, Shaoqiu; Zhang, K.; Li, Zili; Science Foundation Ireland
This paper reviews previous published articles on structural health monitoring (SHM) of tunnels using distributed fibre optic sensing (DFOS). The installation of DFOS sensors onto curved surfaces in tunnels, such as the transverse cross section of a tunnel, is a major challenge for the effectiveness of SHM of tunnels. The state-of-the-art DFOS sensors installation methods currently used for monitoring surface strains in tunnels are summarized, with emphasis on evaluating the applicability scenario of each method and their advantages and disadvantages.
RÉSUMÉ: Ce document est un recueil d'articles publiés précédemment sur le contrôle de la santé structurelle (SHM) des tunnels au moyen de la détection distribuée par fibre optique (DFOS). L'installation de capteurs DFOS sur des surfaces courbes dans les tunnels, telles que la section transversale d'un tunnel, est un défi majeur pour l'efficacité du SHM des tunnels. Les méthodes d'installation des capteurs DFOS actuellement utilisées pour contrôler les contraintes de surface dans les tunnels sont résumées, en mettant l'accent sur l'évaluation du scénario d'applicabilité de chaque méthode et sur leurs avantages et inconvénients.
The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency
(John Wiley and Sons Inc, 2022) O'Halloran, Ken D.; Science Foundation Ireland
Endogenous medullary raphé hydrogen sulphide facilitates the ventilatory response to hypercapnia
(John Wiley and Sons Inc, 2021) Condon-English, Finbarr J.; O'Halloran, Ken D.
Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats
(Elsevier, 2020) O'Connor, Karen M.; Lucking, Eric F.; Bastiaanssen, Thomaz F. S.; Peterson, Veronica L.; Crispie, Fiona; Cotter, Paul D.; Clarke, Gerard; Cryan, John F.; O'Halloran, Ken D.; Science Foundation Ireland
Background: Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if treatment with prebiotics ameliorates cardiorespiratory dysfunction in CIH-exposed rats. Methods: Adult male rats were exposed to CIH (96 cycles/day, 6.0% O2 at nadir) for 14 consecutive days with and without prebiotic supplementation (fructo- and galacto-oligosaccharides) beginning two weeks prior to gas exposures. Findings: CIH increased apnoea index and caused hypertension. CIH exposure had modest effects on the gut microbiota, decreasing the relative abundance of Lactobacilli species, but had no effect on microbial functional characteristics. Faecal short-chain fatty acid (SCFA) concentrations, plasma and brainstem pro-inflammatory cytokine concentrations and brainstem neurochemistry were unaffected by exposure to CIH. Prebiotic administration modulated gut microbiota composition and diversity, altering gut-metabolic (GMMs) and gut-brain (GBMs) modules and increased faecal acetic and propionic acid concentrations, but did not prevent adverse CIH-induced cardiorespiratory phenotypes. Interpretation: CIH-induced cardiorespiratory dysfunction is not dependant upon changes in microbial functional characteristics and decreased faecal SCFA concentrations. Prebiotic-related modulation of microbial function and resultant increases in faecal SCFAs were not sufficient to prevent CIH-induced apnoea and hypertension in our model. Our results do not exclude the potential for microbiota-gut-brain axis involvement in OSA-related cardiorespiratory morbidity, but they demonstrate that in a relatively mild model of CIH, sufficient to evoke classic cardiorespiratory dysfunction, such changes are not obligatory for the development of morbidity, but may become relevant in the elaboration and maintenance of cardiorespiratory morbidity with progressive disease. Funding: Department of Physiology and APC Microbiome Ireland, University College Cork, Ireland. APC Microbiome Ireland is funded byScience Foundation Ireland, through the Government’s National Development Plan.
Modelling of TR-XTREME™ ductile iron pipe under direct tension force
(2022-10-27) Zhang, Qinglai; Chiu, Shih-Hung; Han, Tianyu; Soga, Kenichi; Li, Zili